ANTI-PHOSPHO-ATM-S1981 ANTIBODY PRODUCE+

Code: SAB5700279-100UL D2-231

General description

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus...


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General description

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Immunogen

A synthetic phosphorylated peptide around S1981 of human ATM (NP_000042.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration1.02 mg/ml
formbuffered aqueous solution
Gene Informationhuman ... ATM(472)
mol wt350
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.−20°C
technique(s)immunofluorescence: 1:50-1:200, western blot: 1:500-1:2000
UniProt accession no.Q13315
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